Effect Of Vitamin B7 On Metabolic Disorders

B.Sc Clinical Nutrition & Dietetics coureses in hyderaabad

Biotin, or vitamin B7, is essential to the body’s many metabolic functions. It is essential for producing energy from proteins, lipids, and carbs. Metabolic diseases such as fatty acid metabolism problems and glucose intolerance can result from a lack of biotin. Furthermore, biotin is necessary to keep skin, hair, and nails healthy.

The metabolic processes of gluconeogenesis, fatty acid synthesis, and amino acid metabolism all involve the coenzyme biotin, often known as vitamin B7. During fasting periods or low carbohydrate consumption, the process known as gluconeogenesis is critical because it allows the body to produce glucose from non-carbohydrate sources. In addition to helping to convert fatty acids into forms that can be used for energy production, biotin is necessary to keep energy levels stable.

Impairment of gluconeogenesis:

The enzymes involved in gluconeogenesis, which is how the body makes glucose from non-carbohydrate sources like glycerol and amino acids, depend on biotin. A lack of biotin can cause problems with gluconeogenesis, which lowers the generation of glucose and increases the risk of hypoglycaemia (low blood sugar)

Metabolism of fat acid:

The synthesis, oxidation, and elongation of fatty acids all depend on biotin as a cofactor. Inadequate biotin levels have the potential to interfere with these functions, resulting in the build-up of fatty acids inside tissues and a reduced ability to use fats as an energy source. This may exacerbate symptoms like exhaustion, weakness, and abnormalities in metabolism.

Metabolism of amino acids:

• leucine is among the amino acids that biotin aids in the metabolism of. One important branched-chain amino acid that is broken down by enzymes that are dependent on biotin is leucine. A deficiency in biotin may hinder this process, which may result in increased levels of branched-chain amino acids and associated metabolic problems.

Several scleroses

• There is some data indicating that supplementing with biotin may help reduce the symptoms of Progressing multiple sclerosis. High-dose biotin may help some people with progressive multiple sclerosis (ms) improve their disability and disease progression, according to studies.

Skin suitability

• Biotin is occasionally used in conjunction with other therapies to treat skin diseases like eczema and seborrheic dermatitis. Some people claim that taking supplements of biotin helps with their symptoms, despite the paucity of studies on its efficacy.

Issues with hair and nails

The synthesis of keratin, the protein that gives hair and nails their structure, depends on biotin. Taking biotin supplements may encourage healthier, thicker hair and strengthen weak nails. Supplementing with biotin has been found to improve nail thickness and decrease nail splitting in certain trials.

Disorders of mood and depression:

Biotin may help to maintain normal brain function because it is involved in the creation of neurotransmitters. Although there is no data on the direct benefits of biotin on mood disorders, some people claim that taking supplements of biotin improves their mood and general well-being. To fully comprehend the possible advantages for depression and other mood disorders, more research is required.

Muscle pain and cramps:

Due to its involvement in energy metabolism and muscular function, a biotin shortage has been related to discomfort and cramping in the muscles. Biotin supplements may help reduce soreness in the muscles and enhance general muscular health, but further research is required to substantiate this claim.

The state of cardiac health:

According to some research, biotin may help reduce homocysteine levels, an amino acid linked to an increased risk of heart disease, hence having cardioprotective effects. In addition to other b vitamins, biotin supplements may help heart health by lowering cardiovascular risk and fostering a healthy homocysteine metabolism.

Mental health issues:

The involvement of biotin in nerve function and myelin regeneration raises the possibility of advantages for neurological conditions other than multiple sclerosis, including neuropathies, neurodegenerative illnesses, and cognitive decline.

Management of weight:

The metabolism of proteins, lipids, and carbs—all important for generating energy and preserving a healthy weight—is aided by biotin. According to certain research, taking supplements of biotin may boost weight loss attempts by increasing metabolism and encouraging the breakdown of fat. Nevertheless, additional investigation is required to ascertain the efficaciousness of biotin in managing weight.

Skin health:

By promoting the manufacture of collagen, a protein that makes up the structural structure of bones, biotin helps to preserve healthy bones. Enough biotin may help maintain the strength and integrity of bones, lowering the risk of osteoporosis and fractures.

Visual health:

Carotenoids are substances with antioxidant qualities that promote eye health and guard against age-related macular degeneration (amd) and other eye conditions. Biotin is involved in the synthesis of these chemicals. Although there is no data focused on the impact of biotin on eye health, maintaining appropriate biotin levels may help protect the health of your eyes indirectly because of its role in antioxidant and general metabolism.


Supplementing with vitamin b7 (biotin) may have therapeutic benefits for a variety of medical disorders, such as immune system function, weight management, liver health, bone health, cognitive decline, and eye health. To completely comprehend its mechanisms of action and effectiveness in these areas, more research is necessary. As usual, it’s best to speak with a healthcare provider before beginning any new supplement regimen, particularly if you’re trying to manage a particular health problem.

While biotin deficiencies are rare, they can occur in certain circumstances, such as prolonged antibiotic use or excessive consumption of raw egg whites, which contain a protein that binds biotin and prevents its absorption. Symptoms of biotin deficiency can include thinning hair, brittle nails, skin rash, and neurological symptoms like depression and fatigue.

Supplementation with biotin is commonly used to improve the health of hair, skin, and nails, although more research is needed to confirm its effectiveness for these purposes. Biotin supplements are generally considered safe when taken at recommended doses, but high doses can potentially cause adverse effects and may interact with certain medications.

To Get More information:

Leave a Reply

Visit Us On TwitterVisit Us On FacebookVisit Us On PinterestVisit Us On YoutubeVisit Us On LinkedinVisit Us On Instagram